The 28-Day Menstrual Cycle

The 28-Day Menstrual Cycle Is Not Just a Period

While the menstrual cycle is commonly associated with fertility and pregnancy, its significance extends beyond reproduction and is crucial for overall women’s health. This can be directly attributed to the hormonal fluctuations of estradiol and progesterone that occur throughout the typical 28-day menstrual cycle, which play a vital role in the well-being of not only reproductive women, but may be the key to health for non-reproductive women, particularly for women entering perimenopause and menopause.

Don’t take our word. The importance of the menstrual cycle is now Mainstream. Reputable medical organizations, such as the American College of Obstetricians and Gynecologists (ACOG) in collaboration with the American Academy of Pediatrics, have emphasized the importance of a healthy menstrual cycle. In fact, their publication “Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign” underscores their belief that menstruation serves as an important indicator of overall health in females.

Here, we will explore some of the many benefits of these hormones as they are being produced in a monthly rhythm and why it’s important to understand the menstrual cycle beyond just reproductive function.

A Healthy 28 Day Menstrual Cycle is Pivotal for Vitality

Estradiol at Physiologic Levels Protects the Heart

Endothelial progenitor cells (EPCs) are bone marrow–derived cells that stimulate new blood vessles to form and repair damaged cells inside the heart
Surging estradiol levels during the first half of a menstrual cycle allows EPCs from bone marrow to pool in the blood vessels of the heart
Cyclic bone marrow stimulation and cardiovasuclar health may be reestablished by restoring the natural, monthly cycle of estradiol.

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Progesterone Needed for Breast Health

Apoptosis is a natural and regulated process of cell death that occurs during an organism’s growth or development
Progesterone accomplishes apoptosis by stimulating tumor suppressive proteins/genes such as P53 and P27
Peak progesterone levels during the 2nd half of the menstrual cycle effectively push breast cells into apoptosis

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What Builds Bone? Progesterone

Women need at least 5 ovulatory menstrual cycles per year with optimum levels of progesterone in order to see beneficial bone changes
Without adequate levels of progesterone, women may experience a yearly bone loss of at least 1%
Surging levels of progesterone in the 2nd half of the menstrual cycle is vital to building bone

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Estradiol’s Peak Stimulates the Guardian of the Genome

P53 acts as a tumor suppressor. It allows for DNA repair or stimulates cell death in cells with serious DNA damage
Estradiol activates the tumor-suppressive P53 protein in a concentration-dependent manner
Restoring monthly, surging levels of estradiol may reestablish the turmor suppressing activity of P53 in menopausal women

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Estradiol Maximally Promotes the Expression of Progesterone Receptors

Progesterone therapy requires production of progesterone receptors for efficacy
Clinical evidence supports that the production of progesterone receptors is stimulated by the pre-ovulatory surge of estradiol – and is the highest during estradiol’s peak level at around day 12 of the menstural cycle
Restoring monthly, suring levels of estradiol may restore optimal progesterone reception and activity, having broad implications for restoring health

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Getting in tune with your cycle using Physiologic HRT

Understanding monthly hormone rhythms and mechanisms has allowed WHN to develop the Physiologic Hormone Restoration program that establishes just the right doses of estradiol and progesterone. By mimicing the natural hormone cycle of your body, Physiologic Hormone Restoration is designed to restore the normal growth and growth modulation pattern that supports health and function in cells and tissues.

WANT TO LEARN MORE? BECOME A PROVIDER

Interested in learning more about the Physiologic Hormone Restoration Program? Get started by enrolling in WHN’s FREE Physiologic HRT Training and Coaching Program.

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Find a Physiologic HRT Provider

Every person’s body is different. There are many genetic, health and lifestyle factors to consider for hormone restoration. It’s important to work with a practitioner you can trust.

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The Mission of WHN is to expand the Standard of Care by promoting, advocating, and advancing women’s wellbeing and longevity through clinical research and education about the benefits of Physiologic Restoration™ to reduce the symptoms of hormone imbalance, chronic disease and degenerative decline.

WHN is a registered 501(c)3 not-for-profit corporation